EZH2 CONTROLS AN EARLY HEMATOPOIETIC PROGRAM AND GROWTH AND SURVIVAL SIGNALING IN EARLY T CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA

Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia

Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs.Inactivating alterations of Polycomb repressive complex 2 components are frequent in human ETP-ALL, but their functional role is largely undefined.We have studied the involvement of

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2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression

Magnolia officinalis is widely used in Southeast Asian countries for the treatment of fever, headache, diarrhea, and stroke.Magnolol is a phenolic compound extracted from M.officinalis, with proven antibacterial, antioxidant, anti-inflammatory, and anticancer activities.In this study, we modified magnolol to synthesize a methoxylated derivative, 2-

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